Hyaluronic acid (HA) variously called “Nature’s Moisturiser” or “Fountain of Youth” is found throughout the body as it forms part of the structural tissue that holds tissues together. Almost half (7.5 grams) of HA in the body is located in the collagen of skin, acting as a moisture retaining gel. Scientific studies have shown that HA improves skin and tissue hydration; works as a free radical scavenger; and stimulates the production of collagen in the skin. HA itself has a short lifespan and the body must produce it each day to maintain the levels necessary for the repair and regeneration of tissues lost through wear and tear. As we age the production of HA in the body decreases. Fibroblasts, which produce collagen, elastin and fibronectin to provide strength, structure and elasticity to the skin, slowdown and become less active and produce less HA. As HA levels become depleted, collagen fibres bind together into more rigid fibres known as Collagen Type-1 leading to older facial looks. Increasing the HA levels by supplementation can promote Collagen Type -111 which gives a more youthful facial look. The unique viscous nature of HA and the fact that it does not stimulate immune or allergic responses and is extremely well tolerated in the body has led to its use in a number of clinical applications. A major breakthrough has been the development of a liquid formulation of HA which is rapidly absorbed in the gut and can appear in the body in less than sixty minutes (J. Agric. Food Chem.2008, 56, 10582-10593)
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